GLP-1 medications are a class of prescription drugs that not only improves blood sugar control but may also lead to weight loss. This class of drugs is commonly called glucagon-like peptide 1 (GLP-1) agonists. Weight loss can vary, depending on which GLP-1 drug you use and the dosage. Studies found people using Semaglutide and making lifestyle changes lost about 33.7 pounds (15.3 kilograms) versus 5.7 pounds (2.6 kilograms) in those who didn’t use the drug. GLP-1 medications are generally taken by an injection given weekly, depending on the drug (Semaglutide, Tirzepatide).